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When this medication is used with radiation treatment, it may rarely increase the risk of tissue and bone damage. Tell your doctor right away if you have symptoms such as irregular heartbeat, low back/side pain, signs of kidney problems (such as pink/bloody urine, change in the amount of urine, painful urination), or muscle spasms/ weakness. Also, your doctor may prescribe an additional medication. To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. When used to treat tumors, methotrexate sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). Tell your doctor right away if new lumps/growths occur. The drug must be stopped and treatment may be needed. Lumps (tumors/abnormal growths) may very rarely appear during methotrexate use.
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Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis). If you are using methotrexate long term, a liver biopsy is usually recommended. In rare instances, this drug may also cause liver problems when it is used for long periods of time. Ask your doctor or pharmacist for more details on the safe use of these drugs (such as close monitoring by your doctor, keeping the same doses of NSAIDs). If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. NSAIDs/ aspirin may be used with low-dose methotrexate such as for the treatment of rheumatoid arthritis if directed by your doctor. Caution is advised if you also take aspirin. NSAIDs should not be used with high-dose methotrexate. Methotrexate (usually at high dosages) has rarely caused severe (sometimes fatal) blood/ bone marrow problems (decreasing your body's ability to fight infections) and stomach/intestinal disease (such as bleeding) when used at the same time as non-steroidal anti-inflammatory drugs ( NSAIDs such as indomethacin, ketoprofen).
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If you have kidney problems or excess body water ( ascites, pleural effusion), you must be closely monitored and your dose may be adjusted or stopped by your doctor. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. Women must avoid becoming pregnant while using this medication. Methotrexate has caused birth defects and death in unborn babies.
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Methotrexate formulations with preservatives must not be used for high-dose treatment or injected into the spine ( intrathecal). This medication should be used only to treat cancer or severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis). It works by blocking the activity of a protein TNF?, thereby suppressing the function of white blood cells (macrophage and T-cell), reducing the inflammation in joints, and preventing new erosions.Methotrexate has rarely caused serious (sometimes fatal) side effects. Intacept (Etanercept) 25 mg ,50mg injection a disease modifying anti-rheumatic drug, belongs to a class of medications called TNF? inhibitor. It is also used to treat polyarticular juvenile idiopathic arthritis (arthritis in children and adolescents of no defined cause), psoriatic arthritis (arthritis that affect people having chronic skin disease called psoriasis), ankylosing spondylitis (spinal arthritis that causes fusion of spinal and pelvic joints), in patients not responding to other medicines. Intacept (Etanercept) 25 mg ,50mg injection is used either alone or in combination with other medicines to treat rheumatoid arthritis. It works by blocking the activity of a protein (TNF?) thereby suppressing white blood cells function (macrophage and T-cell), reducing the inflammation in joints, and preventing new erosions (disease modifying action).Īnkylosing Spondylitis, Rheumatoid Arthritis, Juvenile idiopathic arthritis Remicade 100mg injection is a disease modifying drug that belongs to a class of medications called TNF? inhibitors. It is also used to treat Crohn’s disease (serious inflammation of gastrointestinal tract) and ulcerative colitis (disease that causes ulcers on the lining of the large gut).
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Remicade 100mg injection is used in adults to treat rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet), psoriasis or psoriatic arthritis (arthritis associated with a skin disease called psoriasis) and ankylosing spondylitis (spinal arthritis causing ankylosis of vertebral and sacroiliac joints).